Sponsored by the Biomedical Engineering Institute
and the Center for Interfacial Engineering
University of Minnesota, Twin Cities
For the past decade intense research in biomaterial science and tissue engineering has evolved from an occasional crossing-of-paths to a growing mutual dependence. The technological needs in tissue engineering have given biomaterial science research a new dimension; conversely, advances in biomaterial science have transformed tissue engineering from imagination to achievable goals. The interweaving interests of the two specializations will continue to intensify and a new era of tissue engineering is emerging. However, despite the great advances in the past decade, our understanding of tissue material science is still modest. Biomaterials confer physical and chemical modulation to cell growth and differentiation. Conversely, growing cells also continuously modulate the physical and chemical properties of the biomaterials.
The interactions between biomaterials and developing tissue have been largely uncontrolled. Can a new generation of biomaterials be developed to deliver physical and chemical signals inductively by sensing the developmental stages of growing tissues? Can the developing tissues be "instructed" to modulate the physical or chemical characteristics of the supporting biomaterials dynamically? Opportunities for research and development in tissue biomaterial science abound; creative innovations are called for. However, many scientific and technological challenges must be surmounted before the market potential develops into widespread demand. Is the technology for transforming engineered tissue into manufacturing processes attainable? This workshop will address vital technical issues related to tissue biomaterial science. Technical keynote lectures will focus on state-of-the-art review and long-range technological and market projections. Each keynote lecture will be followed by open discussion. Realistic assessment of long-range potential will be discussed.
This workshop is to be held in conjunction with the semiannual meeting of the Center for Interfacial Engineering (CIE) at the University of Minnesota (September 22–23). The semiannual meeting is a showcase of oral and poster presentations of CIE research on a wide range of projects, including surfactancy, coating flow, polymer processing and biological interfacial phenomena. Information about the technical program is available through the Internet at http://www.cie.umn.edu or by contacting CIE at 612-626-2230. The semiannual meeting is open only to scientists and engineers of member institutions, but arrangements can be made for individuals from non-member institutions to attend by contacting Connie Hempstead at CIE at 612-626-9509.
KEYNOTE SPEAKER
Yoshito Ikada, Kyoto University
Prof. Ikada is an internationally renowned researcher in biomaterials. Educated as a polymer chemist, Dr. Ikada first began his research career at the Polymer Chemistry Department at Kyoto University after obtaining his Ph.D. He subsequently received a second Ph.D. in medicine from the Medical School of Kyoto University. He became the Director of the Center for Medical Polymers and Biomaterials in 1988. He was the founding Director of the Center for Biomedical Engineering at Kyoto University from 1990 to 1992 and was the President of the Japanese Society for Biomaterials from 1992 to 1996. Over the past decade Dr. Ikada’s research has ranged from polymers to biomaterials, from polymeric prosthetics to tissue engineering. This keynote lecture will also give the audience a global perspective of tissue biomaterial science.
Professor Ikada will be a Visiting Professor at the Department of Chemical Engineering and Materials Science and the Biomedical Engineering Institute at the University of Minnesota in September and October of 1997.
INVITED SPEAKERS
George A. Truskey, Duke University
George Truskey received a B.S.E. in Bioengineering from the University of Pennsylvania in 1979 and a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 1985. He served as a Research Fellow in the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School and as an Assistant Professor of Chemical Engineering at Tufts University. In 1987 Dr. Truskey joined the faculty of the Department of Biomedical Engineering at Duke University where he is currently an Associate Professor. He is also a member of the Center for Cellular and Biosurface Engineering at Duke. Professor Truskey's research interests are endothelial cell adhesion to biomaterials, fluid mechanical factors affecting endothelial cell function and lipoprotein transport into the arterial wall.
Matthew V. Tirrell, University of Minnesota
Matthew Tirrell received his undergraduate chemical engineering education at Northwestern and his Ph.D. in polymer science and engineering at the University of Massachusetts, working with Stanley Middleman. He joined the Department of Chemical Engineering and Materials Science at the University of Minnesota in 1977 and is now the Head of that department, where he holds the Earl E. Bakken Chair in Biomedical Engineering. Matt has also done research during sabbatical leaves at ƒcole Superieure de Physique et Chimie in Paris, at the Australian National University in Canberra, and at Bell Laboratories. His research interests are in manipulating and measuring surface properties of polymers. Matt has been a leader in bringing microscopic measurements of intermolecular forces to bear on polymer surface problems. He and his coworkers have brought significant new insights into polymer technology, particularly in the area of surface modification with amphiphilic polymers, and biomolecular materials. He has supervised more than 40 Ph.D. students at Minnesota and is a co-author of more than 200 scientific articles and one book, Polymerization Process Modeling, published last year. Matt has received other awards including the Camille and Henry Dreyfus Teacher-Scholar Award, Sloan and Guggenheim Foundation Fellowships, the Allan P. Colburn, Charles M.A. Stine and Professional Progress Awards of AIChE and the John H. Dillon Medal of the American Physical Society. He serves on twelve editorial advisory boards for journals and book series and, since 1991, has been the Editor of AIChE Journal. In 1997, he was elected to the National Academy of Engineering.
Dr. Mark Applegate, Advanced Tissue Sciences, Inc.
Mark Applegate is currently Sr. Group Leader of Product Development for Advanced Tissue Sciences in LaJolla, California, helping to develop and commercialize the first generation of tissue-engineered products. Prior to joining ATS, Mark helped successfully commercialize several new hydrocolloid products made by fermentation at Merck's Kelco Division from 1992 to 1995. Mark received his Ph.D. in Chemical Engineering from M.I.T. in 1991 under the direction of Prof. Gregory Stephanopoulos in the area of bioreactor design for immobilized cell culture processes. He received his B.Ch.E. degree with Distinction from the University of Delaware. He has authored several papers and holds patents in the field of bioprocess engineering.
Lillian W. Chiang, Stanford University
Lillian W. Chiang received her B.S. in Life Science at the Massachusetts Institute of Technology and her Ph.D. in Bacteriology from the University of Wisconsin, Madison. She is currently finishing postdoctoral research in the Department of Neurobiology at Stanford University. In order to further understanding of the mechanisms of learning at the molecular and cellular level, Dr. Chiang has applied cDNA microarray technology for the monitoring of gene expression that is required for memory consolidation in rats. She was a National Research Service Award fellow and received predoctoral awards for research excellence from the Association for Women in Science and the University of Wisconsin Bacteriology Department.
Dennis L. Polla, University of Minnesota
Dennis L. Polla received his undergraduate education at M.I.T. and Ph.D. and M.B.A. from the University of California, Berkeley. He is currently a Professor in the Department of Electrical and Computer Engineering and Department of Laboratory Medicine and Pathology at the University of Minnesota. He also serves as the Director of the Microtechnology Laboratory and is an Associate Director for Research in the Biomedical Medical Engineering Institute. Professor Polla’s research interests are in biomedical microelectromechanical systems, materials physics, and integrated circuits. Dr. Polla is a former Presidential Young Investigator and 1995 recipient of a W. M. Keck Award for Engineering Teaching Excellence.
A poster session will be held in the afternoon of the workshop. A limited amount of space is available for presentation of posters related to biomaterials and tissue engineering.
Biomedical Engineering Institute
The Biomedical Engineering Institute (BMEI) is a new, cooperative enterprise between the University of Minnesota’s Medical School, Institute of Technology, and the biomedical industry in the Twin Cities. BMEI is a developing organization that possesses certain characteristics of a biomedical engineering department and certain features of a research institute with an annual budget of over $1 million.
The mission of BMEI is education, research, and service. The two major research focus areas are the tissue-materials science interface and biomedical microelectronic mechanical systems (MEMS). It endeavors to harness and increase the diverse biomedical engineering talent at the University and bring it into more productive collaboration with biomedical industry.
Center for Interfacial Engineering
The Center for Interfacial Engineering (CIE) is a National Science Foundation Engineering Research Center. With funding by NSF and additional support from the University of Minnesota, the state, and industry, the CIE has an annual budget of over seven million dollars.
Interfacial engineering deals with the production of a myriad of microstructures that form the building blocks as well as the final products of interfacial systems. CIE’s research program deals with a wide variety of materials ranging from macromolecular molecules that control life processes to surface modifying agents, blends of polymers used to tailor specific material properties or coating processes. All these research areas share a common fundamental knowledge base–the molecular interactions that occur at the boundary between two materials. CIE’s research also focuses on optimizing interfacial processing technologies plays a key role in the long-term economic health of many vital industries.
For further information, please contact:
Department of Chemical Engineering and Materials Science
University of Minnesota
Telephone: 612-626-0587
Fax: 612-626-7246
E-mail: acre@cems.umn.edu
Registration deadline: September 5, 1997
The University of Minnesota is an equal opportunity educator and employer.