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 Marching on in its third year, the CHO consortium recently welcomed its 9th member, and embarks on an effort to sequence the genome
20 years of CHO cells
Biotechnology Training Program
Dr. Hu is directing the NIH funded Biotechnology Training Program, which promotes interdisciplinary training on biotechnology. The program supports 15 students from various departments on campus.
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This intensive short
course is an abbreviated version of the annual course offered at the University of Minnesota. The course is specifically designed for engineers, cell biologists, and scientists interested in
state-of-the-art cell culture technology. This course
has thus far attracted participants from more than 35 countries since
it was first offered in 1986. The course focuses on the fundamentals
of cell biology and biochemical engineering.
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| Recent Events |
 The annual Cellular Bioprocess Technology course was held at the University of Minnesota in June 16-19, 2008. This course has played a key role in training thousands of cell culture bioprocessing professionals. Last year's course was attended by over 60 people representing 10 countries.
This hands-on workshop was held June 19-20, 2008. The workshop covered fundamentals of microarray data analysis with references to proteomic analysis
Symposium on Engineering Stem Cells
Professor Peter Zandstra of the University of Toronto, is periodically visiting the Stem Cell Institute in 2008 to give a series of lectures, and to facilitate research and training collaborations on stem cell engineering. Abstract PDF
Asia Pacific Biochemical Engineering Conference
November 4 - 8, 2007- Taipei, Taiwan. This conference will bring together experts from all relating fields to further the understanding of biotechnology. Click here to see some of the featured keynote speakers.
2007 Annual Meeting, Society for Industrial Microbiology
Celebrating 20 years of success, this successful Cell Culture Engineering session was was held July 29-31, 2007 in Dever, CO, and was organized by Dr. Gargi Seth, Dr. David Chang and Dr. Wei-Shou Hu. |
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HuGroup members present at Stem Cell Enigneering conference and ACS
HuGroup members Kartik Subramanian, Kathik Jayapal, and Yonsil Park presented the following at the 2007 ACS annual meeting in Boson .
MAPC (an adult stem cell) Differentiation to liver cell in 3D (Kartik Subramanian)
Global qualification of protein Half Life (Karthik Jayapal)
MAPC pluri ptency and oxygen/cell density (Yonsil Park)
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| Recent Work |
Advancing Mammalian cell culture Engineering using Genome-scale technologies
A concise review on the recent applications of transcription and proteome analysis in cell engineering.
(Griffin, T. et al. 2007. Trends Biotechnol, 25, 401-408)
Engineering Cell Metabolism for High Density Cell Culture via Manipulation of Sugar Transport
By empowering cells with the capability to utilize fructorse, lactate production is reduced.
(Wlaschin, K. et al. 2007. J. Biotechnol. 131, 168-176)
Comparative genomics of Streptomyces coelicolor and Streptomyces lividans
Comparative genomic hybridizations reveal differences between the chromosomes of S. coelicolor and S. lividans. Absence of certain large genomic islands in S. lividans identified appear to make it more suitable for cloning and protein secretion.
(Jayapal. K. et al. 2007. BMC Genomics. 8, 229)
Transcriptome dynamics based operon prediction and verification in Streptomyces Coelicolor
A compilation of global transcriptome data was used to build and verify a genome-scale operon map for Streptomyces coelicolor using a machine learning algorithm – support vector machines (SVM).
(Charaniya, S. et al. 2007. Nucl. Acids Res. 35 (21) 7222-7236)
Books on Cell Culture Engineering
Dr. Hu has recently collaborated on two books, Cell Culture Engineering and Cell Culture Technology for Pharmaceutical and Cellular Therapies, which were published in 2006.
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In Pursuit of a Super Producer - Alternative Paths to High Producing Recombinant Mamalian Cells
A discussion on the gene expression changes that give rise to hyperproductivity.
(Seth, G. et al. 2007. Current Opinion in Biotechnol. 18, 557-564)
Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity
At a transcriptome level MAPC is in between mesenchymal stem cells and embryonic stem cells.
(Ulloa-Montoya, F. et al. 2007. Genome Biol 2007. 8:R163)
A Scaffold for the chinese hamster genome
A description of synteny between chinese hamster to mouse.
(Wlaschin, K. et al. 2007. Biotechnol Bioeng. 98, 429-439)
Systems Analysis of N-Glycan Processing in Mammalian Cells
A theoretical model to predict the metabolic engingeering target(s) for producing uniform glycans on glycoprotein therapeutics.
(Hossler, P. et al. 2007. PlosOne. 2(8) 429-439)
Comparative Transcriptome/Proteome of Hyper Producers
(Seth, G. et al. 2007. Biotechnol Bioeng. 93 933-951) |
| Inside the HuGroup |
The People
Meet the faculty, staff and students who form the Hu Group.
Former Group Members
The Hu Group is proud of its former students, scholars and staff who set the standard of excellence we continue to strive for.
Year of the Pig Greeting |
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Life in the Hu Lab
The Hu Group returns from its annual weekend retreat and workshop to Itasca State Park where they also enjoyed Minnesota's winter outdoor activities. |
| Congratulations to our recent Ph.D. recipients |
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